臨床医学領域からの個体差研究への提言

概要

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This paper deals with clinical research of personal sensitivity to alcohol intakes: average daily alcohol intake (ADAI) (g/day) and total alcohol intake (TAI) (kg) with a use of serum γ-glutamyltranspeptidase (γ-GTP) activity. In contrast to a positive correlation between γ-GTP and TAI (r=0.4856,P<0.001) in social drinkers, a significant negative correlation (r=-0.4999,P<0.001) was observed in chronic alcoholics, strongly suggesting a "poor responder" to drinking. In addition, the "poor responder" is defined to be a significant elevated alcohol intakes such as ADAI(160g/day) and TAI(1122kg), in spite of almost normal range of γ-GTP activity (34mU/mL). Moreover, the "poor responder" is characteristic of muscular body image in Kretchmer's classification ,less withdrawal syndrome and almost none of intorelable signs even on the occasion of initial drinking. Personal sensivity to drinking is also discussed in special reference to polymorphism of genomic types of alcohol metabolyzing enzymes (alcohol dehydrogenase ADH2 and acetoaldehyde dehydrogenase ALDH2).
日本ビタミン学会の論文
2008-03-25