劇症肝炎における動的赤血球膜物性検査

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Hemolysis end point (HEP), a quantitative index of osmotic fragility of red blood cells, was determined by means of coil planet centrifuge system or CPC method (designated, "observed HEP"). The assay was done in 20 normal subjects md 256 times of patients with diseases of the liver and biliary tract, including 56 acute hepatitis and 5 fulminant hepatitis. In addition, HEP was also computed by stepwise regression analysis, using 7 itms of blood biochernistry such as GOT, GPT, cholinesterase, α1-lipoprotein (α1-Lp), total cholesterol, albumin and bilirubin which ware simultaneously measured (designated, "computed HEP"). In general, observed HEP values were closely related to change in individual biochemical tests during the clinical course of the diseases, in the exception with fulminant hepatitis. In contrast to acute hepatitis, low HEP values rather restored toward normal in fatal cases of fulminant hepatitis, despite deterioration of individual biochemical data. This observation was fhrther supported by the fact that a positive deviation of observed HEP from the computed HEP was enlarged during the clinical course of fulminant hepatitis, indicating a poor prognosis. It was also revealed that either hepaplastin test or α1-Lp in combination with observed HEP were useful for evaluating severity of hepatitis: i.e., increasing trend in positive differences between observed HEP md hepaplastin test(or α1-Lp) also indicated a poor prognosis in fulminant hepatitis.
社団法人日本肝臓学会の論文

劇症肝炎における動的赤血球膜物性検査

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