A CASE OF GASTRIC CARCINOMA WHOSE SERUM WAS POSITIVE FOR ALPHA-FETOPROTEIN, VARIANT ALKALINE PHOSPHATASE AND CEA

概要

論文の詳細を見る
A case of 78-year old man, who was diagnosed of gastric cancer metastatic to the liver and whose serum revealed the presence of 3 different carcinofetal antigens such as alpha-fetoprotein, variant alkaline phosphatase and carcino-embryonic antigen(CEA), was reported. In this case, alphafetoprotein producing cells seemed to be degenerating hepatocytes which were compressed by metastasis. Although synthesizing cells of variant alkaline phosphatase and CEA were studied biochemically using the extracts from the liver free from the cancer and gastric cancer, it was failed to make clear these synthesizing cells because of much contamination of the blood. However, alkaline phosphatase zymogram of the both extracts after treatment with neuroaminidase showed copresence of variant and fetal intestinal alkaline phosphatase which was firstly reported by Higashino et al.As the conclusion, we want to point out now a time for making clear the synthesizing cells of carcino-fetal proteins, although of course these proteins play an important role in clinical fields.
財団法人日本消化器病学会の論文