:HEPATOCARCINOGENESIS INDUCED BY 2-ACETYLAMINOFLUO

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The immuno-biochemical and histological changes of epoxide hydrolase (EH), which was one of the important drug metabolising enzyme in the liver microsomal membrane, was studied by using hyperplastic nodules and hepatocellular carcinoma induced by the intermittent 2-acetylaminofluorene feeding. The amount of EH increased in microsomal fractions of hyperplastic nodules and hepatocellular carcinoma by electroimmunoassay. A single immuno-precipitation line which formed between anti-EH IgG fraction and purified EH, hyperplastic nodular and hepatocellular carcinoma microsome, completely fused each other. By means of the direct immunofluorescent staining, the specific fluorescence of EH was observed in almost all nodular cells in hyperplastic nodules, but was sporadically induced in hepatoma.These results suggest that the detachment or releasement of EH from microsomal membrane occures as a characteristic changes in liver cell transformation during hepatocarcinogenesis.
財団法人日本消化器病学会の論文