<論文>内視鏡を用いた電気インピーダンス測定による胃癌の診断に関する研究

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As a new functional endoscopic examination, we developed the measurements of gastric mucosal electrical impedance using an endoscope. The impedances were evaluated in some kinds of gastric muscosal lesions in the frequency range of 100Hz-100kHz. Concerning basic examination, the levels of the impedance in rats and dogs were measured by the 2 electrode method. Clinically, in 63 patients with gastric mucosal lesions and normal controls, the levels of them were examined by the single and 2 electrode methods. The Cole-Cole plots were detectable correctly both in the animals and human. The Cole-Cole plots of the patients with gastric cancer were clearly different from those of the controls. Frequency f (X=O), when the reactance is zero, is 10.1±1.2kHz in cancer patients, while f(X=0) is 14.7±2.7kHz in the controls. The both values of R(X=0) and |Z| are lower in the cancer patients than those in the controls. However, f(X=0) shows no remarkable difference between the cancer lesions and their surroundings, while R (X=0) in the cancer lesions dropps significantly against that of their surroundings. These results seem to indicate that the measurements of mucosal impedance were very useful in the diagnosis of the gastric cancer clinically.
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