スクシンイミドエステルの化学-4-N,N1-ジスクシンイミジルカルボネ-ト(DSC)を用いたN-スクシンイミジルカルボキシレ-トの簡易合成法〔英文〕

概要

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A facile preparation of N-succinimidyl carboxylates (N-succinimidyl esters of fatty, substituted benzoic and aliphatic dicarboxylic acids) using N, N'-disuccinimidyl carbonate (DSC) was developed. The reactions of the acids with DSC in the presence of pyridine in acetonitrile gave the corresponding esters in good yield. N-Hydroxysuccinimide formed during a reaction and pyridine could be easily removed by treatment with water. No by-products, of course, could be detected by HPLC and TLC analyses. The present method has advantages of high yields and purities of the desired esters, and of convinience for preparation of the N-succinimidyl esters, compared with the method using N, N'-dicyclohexylcarbodiimide (DCC). The structures of the resulting esters were determinded by mass spectrometry.
日本油化学会の論文