一酸化炭素の作用機序に関する研究 (第1報) : 低濃度一酸化炭素吸入後のCO-Hb飽和度の変化および血糖値変化について

概要

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The purpose of this study was to reveal the physiological effects on rabbits, and inhalated air containig small amounts of CO. This was especially noted on the changes of the percent of saturation of carboxy hemaglobin and blood sugar levels.The flexible film isolator for rearing germ free amimals was applied to make a chamber to flow constantly the desired concentration of CO throughout these experiments.The experimental results were summarized as follows:1) The peak of percentage of saturation of carboxyhemoglobin was observed after inhalation of CO in the concentration of 100ppm. for about 30 to 60 minutes, and its value was decreased gradually in half after 3 hours in spite of the same situation under which the animals breathed. In spite of administration of Epinephrine in order to check the influence with an increased circulatory volume, the value was not decreased under the same CO conditions.2) The inhalation of CO in the concentration of 100ppm. caused the increase of blood sugar levels in rabbits and the peak of the levels was observed after the inhalation for the mean period of 90 minutes. The continuation of hyperglycemia appeared even after discontinuation of inhalation of CO of 300ppm.
日本衛生学会の論文