酪酸菌製剤投与による乳児腸内菌叢の変動

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The purpose of this study is to ascertain the fact that if the oral administration of Miyarisan, a drug for infant, composed of the spores of certain strain of Clostridium butylicum, causes any changes in the population numbers of bacteria among the intestinal bacterial flora residing in the intestine of infant. The drug of 0.6 gr. per day was given orally to infant. The ages of twelve infants were varied from two to six months after birth. The experimental periods of time, which mean consecutive days of administration of the drug, were distributed from three to twenty one days. The bacterial flora, such as Clostridium butylicum, Lactobacillus bifidus, Lactobacillus acidophilus, Streptococcus faecalis and Escherichia coli, were recovered from the faeces of infants using selction culture media suitable for each bacterial strain. Ebbs and flows in bacterial population numbers of the objected strains were as follows ; (1) Cl. butylicum was not recovered through-out all experiments. (2) In all experiments, E. coli did not showed any particular changes in its population numbers. (3) Generally, L. acidophilus, L. bifidus and St. faecalis decreased in their population numbers at the bigining of experiments, but their population numbers increased afterwards. (4) Respect to L. bifidus, ten out of eleven experiments, excluding one experiment, the bacteria showed the tendency of increasing in their population numbers, particularly four out of the ten experiments showed clear increasing in their population numbers. From the above-mentioned results, we could draw the conclusion that the oral administration of Miyarisan possibly played an important role in the multiplication of L. bifidus in the intestines of infants.
千葉大学の論文

酪酸菌製剤投与による乳児腸内菌叢の変動

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