ROLE OF PLASMA CHOLESTEROL IN RAT-ADRENAL CORTICOSTEROIDOGENESIS <I>IN VITRO</I>
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概要
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Rat-adrenal glands were shown to accumulate cholesterol-4-<SUP>14</SUP>C which was administered intraperitoneally. The administered cholesterol entered the adrenal gland in free form and then was transformed gradually to the ester form in the tissue. The results of the present experiments reveal that cholesterol either derived from plasma or biosynthesized <I>in vitro</I> from acetate within cells can serve as the precursor for corticosterone biosynthetsis <I>in vitro</I>. The present results also indicate that mitochondrial cholesterol in free form but not in ester form is utilized for corticosterone biosynthesis. This confirms previous works.
- 社団法人 日本内分泌学会の論文
著者
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小林 森
Division of Physiology and Pathology, National Institute of Radiological Sciences
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ICHII SHOGO
Division of Physiology, Institute of Steroid Research and lst Department of Internal Medicine
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Kobayashi Shigeru
Division Of Anatomy Kyushu Dental College
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YAGO NAGASUMI
Division of Physiology and Pathology, National Institute of Radiological Sciences
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YAGO NAGASUMI
Division of Physiology and Pathology, National Institue of Radiological Sciences
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OMATA SABURO
Division of Physiology and Pathology, National Institute of Radiological Sciences
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OMATA SABURO
Division of Physiology and Pathology, National Institue of Radiological Sciences
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ICHII SHOGO
Division of Physiology and Pathology, National Institue of Radiological Sciences
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