Short-and Long-Term Effect of ACTH <I>in vivo</I> on the Incorporation of <SUP>3</SUP>H-Leucine into the Submitochondrial Fractions from Rat Adrenal Glands
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概要
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Short-(3.5hr) and long-term (3 days) effects of ACTH <I>in vivo</I> on the incorporation of <SUP>3</SUP>H-leucine into cell fractions from rat adrenal glands were examined, with special regard to effects of the hormone on the rate of the amino acid incorporation into submitochondrial fractions. An injection of ACTH caused a significant increase in the rate of the radioactive amino acid incorporation into the inner membrane and soluble matrix fractions of adrenal mitochondria within 3.5 hr while no significant effect of ACTH administration was observed in the other subcellular fractions. Injections of ACTH for consecutive 3 days resulted in the elevated rate of the incorporation into all subcellular fractions except into the acid-soluble fraction. Physiological significance of the results obtained was discussed with respect to the steroidogenic effect of ACTH.
- 社団法人 日本内分泌学会の論文
著者
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ICHII SHOGO
Division of Physiology, Institute of Steroid Research and lst Department of Internal Medicine
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IZAWA MASAO
Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine
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IKEDA AKEMI
Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine
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IZAWA MASAO
Division of Physiology, Institute of Steroid Research, Tottori University School
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ICHII SHOGO
Division of Physiology and Pathology, National Institue of Radiological Sciences
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