Changes in the cytoplasmic androgen receptor of rat ventral prostate after administration of androgens, antiandrogens and anabolic steroids.
スポンサーリンク
概要
- 論文の詳細を見る
The effect of the administration of androgens (testosterone and dihydrotestosterone), antiandrogens (progesterone and cyproterone acetate) and anabolic steroids (Bolandiol, Nandrolone, Furazabol and Methenolone) on depletion and replenishment of the androgen receptor in the cytosol of ventral prostate from castrated rats was examined using <SUP>3</SUP>H-R1881 as the ligand. Administration of androgens lead to a rapid fall in the level of the receptor and the receptor in the cytosol was replenished in the period following treatment. Length of the period of receptor depletion was dependent on the dose of androgen administered. Administration of antiandrogens did not cause any depletion of the receptor and concomitant administration of testosterone induced a pattern similar to that of the depletion observed following administration of testosterone alone. Effect of pretreatment of animals with ethidium bromide, an intercalating dye which has been shown to prevent the <I>in vitro</I> nuclear binding of steroid hormone-receptor complexes, on the depletion of receptor induced by testosterone administration was also insignificant. Anabolic steroids depleted the receptor but the degree of depletion was relatively low. The rate of inhibition of <I>in vitro</I> <SUP>3</SUP>H-R1881 binding by these anabolic steroids was not correlated to the rate of <I>in vivo</I> depletion of the receptor. The significance of these observations is discussed.
- 社団法人 日本内分泌学会の論文
著者
関連論文
- Effect of ACTH on the Phosphorylation of Proteins in Subcellular Fractions of Rat Adrenal Glands
- Studies on the Nuclear Binding of Steroid Hormone-Receptor Complex; Binding of Liver and Thymus Dexamethasone-Receptor Complex and Prostate Dihydrotestosterone-Receptor Complex to Nuclei from Various Tissues
- Nuclei and DNA-Binding Form of the Steroid Receptor Complex in the Liver and the Ventral Prostate of Rats
- Receptor Recycling: Liberation of Glucocorticoid Receptors from Liver Nuclei in vitro
- Effect of ACTH in vivo on the Phospholipid Exchange between Adrenal Microsomes and Mitochondria in vitro
- Interaction of 3H-Dexamethasone-Receptor Complex with Nuclei: Inhibition by Ethidium Bromide
- Effect of Adrenalectomy and Gonadectomy on Protein Turnover of Liver, Kidney and Spleen of Mouse
- Effect of ACTH on Turnover of Phospholipids in Rat Adrenal Glands
- Short-and Long-Term Effect of ACTH in vivo on the Incorporation of 3H-Leucine into the Submitochondrial Fractions from Rat Adrenal Glands
- THE EFFECT OF AGE ON THE ACTIVITY OF CHOLESTEROL SIDE-CHAIN CLEAVAGE IN RAT TESTIS
- Nuclear Binding Sites in the Liver for Dexamethasone and in the Ventral Prostate for R1881
- Effect of Cortisol in vivo on Amino Acid Incorporation into Protein by Rat Liver Ribosomes in vitro
- Studies on Regenerating Adrenal Cortex 2. Autoradiographic and Electron Microscopic Observations
- Adenosine 3, 5-Monophosphate, Adenosine 3, 5-Monophosphate-Binding Protein and Protein Kinase in Rat Adrenal Glands; Fffect of Adrenocorticotrophin
- Effect of ACTH and Dexamethasone on the Rate of Protein and RNA Degradation in Rat Adrenal Glands
- Hormonal Regulation of Protein Synthesis in Rat Ventral Prostate
- ROLE OF PLASMA CHOLESTEROL IN RAT-ADRENAL CORTICOSTEROIDOGENESIS IN VITRO
- STUDIES ON REGENARATING ADRENAL CORTEX 1:STUDIES ON REGENARATING ADRENAL CORTEX 1 INCORPORATION OF 3H-THYMIDINE AND 3H-URIDINE, AND LEVELS OF ADRENAL ASCORBIC ACID, CHOLESTEROL, CHOLESTEROL SIDECHAIN-CLEAVING ACTIVITY,
- Effect of Sex Hormones on the Activity of Protein Kinases in Rat Ventral Prostate and Uterus
- Changes in the cytoplasmic androgen receptor of rat ventral prostate after administration of androgens, antiandrogens and anabolic steroids.