Adenosine 3, 5-Monophosphate, Adenosine 3, 5-Monophosphate-Binding Protein and Protein Kinase in Rat Adrenal Glands; Fffect of Adrenocorticotrophin
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概要
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Concentration of adenosine 3, 5-monophosphate (cAMP), binding activity of cAMP to protein and activities of cAMP-dependent and-independent protein kinase were determined in adrenal glands of rats treated with ACTH (Cortrosyn-Z). cAMP was increased rapidly after 6 U. ACTH injection, reached the maximum level (20-30 times the control) at 10min and returned to the control level by 120min. Hypertrophied adrenals of rats given repeated injections of 3 U. ACTH every 12hr contained a significantly higher amount of cAMP than untreated control. Treatment of animals with ACTH did not modify the activity of cAMP-binding protein throughout the experimental period. cAMP-independent activity of protein kinase was not influenced by ACTH but cAMP-dependent activity of the enzyme disappeared completely immediately after ACTH administration and a part of the activity was restored 80min after the treatment. Administration of cycloheximide prior to ACTH treatment did not disturb the effect of ACTH on cAMP formation and cAMP-dependent protein kinase activity.
- 社団法人 日本内分泌学会の論文
著者
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ICHII SHOGO
Division of Physiology, Institute of Steroid Research and lst Department of Internal Medicine
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ICHII SHOGO
Division of Physiology and Pathology, National Institue of Radiological Sciences
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