Effect of ACTH on Turnover of Phospholipids in Rat Adrenal Glands

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Time-course studies of <SUP>3</SUP>H-choline incorporation into adrenal phospholipids revealed that the specific radioactivity reached to a maximum level at 9 hr after the isotope injection in untreated control animals, while in ACTH-treated animals, a maximum incorporation was already attained by 2 hr postinjection. The effect of ACTH on the incorporation was relatively prompt, the effect became evident as early as 1.5 hr after the treatment of animals. The rate of the incorporation in ACTH-treated animals was about twice that of the control. The incorporated radioactivity was decreased with the half-life of 2.9 days in phospholipids of control adrenals. On the other hand, the incorporated choline was well retained in adrenals of animals which receive daily treatment with ACTH throughout the experimental period of 7 days. The rate of phospholipid exchange between liver microsomes and adrenal mitochondria was not markedly influenced by treatment of animals with ACTH. Physiological implications of these observations were discussed.
社団法人日本内分泌学会の論文