Effect of ACTH on the Interconversion of Ester and Free Cholesterol and Corticosterone Biosynthesis in Rat Adrenal Glands
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概要
- 論文の詳細を見る
After the administration of <SUP>3</SUP>H-and <SUP>14</SUP>C-cholesterol to rats 3 days and 4 hr prior to their death respectively, ester and free cholesterol in adrenal glands were successfully labeled separately with different isotopes. Examination of the <SUP>3</SUP>H/<SUP>14</SUP>C ratio in free and ester cholesterol of adrenal glands and in plasma corticosterone enabled us to study of the role of ester cholesterol in corticosteroidogenesis in ACTH stimulated adrenal glands. By the ACTH administration, the rate of ester cholesterol hydrolysis was increased, while the rate of esterification of free cholesterol was decreased and the hydrolized cholesterol was incorporated into the free cholesterol pool in mitochondria, and then utilized for corticosterone biosynthesis. The administration of cycloheximide did not interfere with the stimulated rate of ester cholesterol hydrolysis in the ACTH-treated adrenals but it prevented the response of plasma corticosterone to ACTH.
- 社団法人 日本内分泌学会の論文
著者
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ICHII SHOGO
Division of Physiology, Institute of Steroid Research and lst Department of Internal Medicine
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IKEDA AKEMI
Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine
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OKADA NORIKO
Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine
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