Alterations in the Functional State of Rat Adrenal following the Lethal and Sub-lethal, Whole-body X-irradiations
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概要
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The effects of whole-body irradiation with lethal and sub-lethal dose (1000 and 600 R) of X-ray on the adrenal function of rats were studied by estimating corticosterone and sterol biosynthesis from ^<14>C-acetate in vitro to assess a functional state of adrenals. At 24 hours post-irradiation, the elevated corticosterone biosynthesis was observed in the adrenals obtained from both 600 and 1000 R X-irradiated rats, while the accelerated incorporation of ^<14>C-acetate into free sterol was noticed in 600 R irradiated adrenals but not in the 1000 R irradiated. At 48 hours after irradiation, the elevated function of 600 R irradiated adrenals was maitained, while in the 1000 R irradiated adrenals, the both corticosterone and sterol formation in vitro were observed to be depressed markedly. The relationship between lethality and adrenal function in irradiated animals was discussed.
- 日本放射線影響学会の論文
著者
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小俣 三郎
Division Of Physiology And Pathology National Institute Of Radiological Sciences
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一井 昭五
Division of Physiology and Pathology, National Institute of Radiological Sciences
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小林 森
Division of Physiology and Pathology, National Institute of Radiological Sciences
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一井 昭五
Division Of Physiology And Pathology National Institute Of Radiological Sciences: (present Address)
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小林 森
Division Of Physiology And Pathology National Institute Of Radiological Sciences
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