PCBの長期間投与によるコイ薬物代謝酵素活性の誘導とその持続性

概要

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A study was made of the induction of drug-metabolizing enzymes by a long-term administra-tion of PCB-diet and also the duration of their induced activities in the hepatopancreas of carp Cyprinus carpio. In a preliminary experiment comparing the inductivity of hepatic drug-oxidase, PCB among the tested environmental contaminants was most effective as the inducer of cytochrome P-450. Therefore, a subsequent experiment was performed to elucidate the effect of long-term administra-tion of PCB (0.05mg/100g-body weight/day) for 16 weeks on drug-metabolizing enzymes in the hepatopancreas of carp. The dietary administration of PCB induced not only the cyt. P-450 content and the activities of aryl hydrocarbon hydroxylase and O-dealkylase, but also the glutathione content and the activities of glutathione- and UDPglucuronosyl-transferase. However, the in-crease of these contents and activities during PCB administration occurred mostly within 2- or 4- week period, resulting in almost no further increase in spite of the continuous PCB administration for 16 weeks. The induced contents and activities were kept for a fairly long time even after dis-continuance of PCB administration.
公益社団法人日本水産学会の論文