クルマエビにおける有機燐剤フェニトロチオンの代謝〔英文〕

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A study has been made of the toxicity, absorption and metabolism of fenitrothion [O, O-dimethyl O-(3-methyl-4-nitrophenyl)phosphorothioate; Sumithion] in tiger shrimp Penaeus japonicus, as the first step to elucidate the cause for the occurrence of its high toxicity to the shrimp.The 24-h LC50 value of fenitrothion for tiger shrimp was about 1 ppb, while that for fish was roughly 6ppm. After 0.5-24h exposure to 0.5 ppb [14C] fenitrothion, [14C]fenitrothion and its metabolites accumulated in the shrimp were extracted with benzene and separated by thin-layer co-chromatography with non-radioactive fenitrothion and its authentic metabolites. After 4-h exposure, the concentration of fenitrothion was almost equilibrated at a level of ca. 6.5pmol/g shrimp, which corresponded to a bioconcentration ratio of 3.6, whereas the concentrations of its metabolites, especially 3-methyl-4-nitrophenol, increased with exposure time. At 24-h exposure, the amounts of fenitrothion, fenitrooxon, desmethylfenitrothion, desmethylfenitrooxon and 3-methyl-4-nitrophenol accumulated in the shrimp were 6.3, 2.9, 3.6, 6.2 and 74.3 pmol/g, respectively. The amounts of the conjugated 3-methyl-4-nitrophenol extracted with ethyl ether after benzene-extraction increased with exposure time and reached 104pmol/g at 24-h exposure, which was almost the same level of the benzene-extract.
社団法人日本水産学会の論文