Inhibitory action of water-extract of cow snout epidermis on mushroom tyrosinase.
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概要
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A tyrosinase inhibitor was found in an aqueous extracts of cow snout epidermis, and the possible mode of action to mushroom tyrosinase was investigated. The inhibitor was non-dialyzable, heat-stable and sulfhydryl-containining compound. The sulfhydryl group of inhibitor was essential in the inhibitory activity. The inhibitor combinded with the lowest mobility isozyme of tyrosinase on DISC electrophresis. The growth curve of. melanoma B-16 cell was not affected by the culture with inhibitor. The biological role of inhibitor on the skin pigmentation could not be revealed in the present study.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hayashi Masao
Department Of Astronomy Graduate School Of Science The University Of Tokyo
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OGURA RYOHEI
Department of Biochemistry, Kurume University School of Medicine
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TAKASHIMA YUKIE
Department of Medical Biochemistry, Kurume University School of Medicine
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TAKEI KAZUTAKA
Department of Medical Biochemistry, Kurume University School of Medicine
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