Riboflavin Deficiency Caused by Treatment with Adriamycin.
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概要
- 論文の詳細を見る
The present study was undertaken to determine whether administration of adriamycin causes the depletion of riboflavin content. Rats received intraperitoneal injections of adriamycin (4mg per kg body weight) for 6 consecutive days. Urinary riboflavin excretion began to increase after 2 days of treatment with adriamycin. Erythrocyte FAD levels decreased gradually and plasma lipid peroxide contents increased markedly at the 6th day. The activity coefficient of erythrocyte glutathione reductase showed a significant increase before the decrease of flavin content and the elevation of lipid peroxide level. Therefore, the value of this coefficient obtained from erythrocyte appears to be a reliable index of riboflavin deficiency, particularly during the early stage.
- 財団法人 学会誌刊行センターの論文
著者
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Ueta Hiroshi
Department Of Gastroenterology And Hepatology Kochi Prefectural Hata Kenmin Hospital
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Hino Yuji
Department Of Surgery Hiroshima City Funairi Hospital
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OGURA RYOHEI
Department of Biochemistry, Kurume University School of Medicine
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SUGIYAMA Masayasu
Department of Medical Biochemistry, Kurume University School of Medicine
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HIDAKA TOSHIHIRO
Department o f Medical Biochemistry, Kurume University School of Medicine
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UETA Hiroshi
Department of Medical Biochemistry, Kurume University School of Medicine
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HINO Yuji
Department of Medical Biochemistry, Kurume University School of Medicine
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