Report of a case of fulminant alcoholic hepatitis.

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A 46-year-old female who died of acute hepatic insufficiency due to alcoholic hepatitis with liver cirrhosis is reported. She was admitted because of fever, jaundice and subcutaneous hemorrhage in both thighs and around the hip joints.<BR>The liver was palpable 2 FB below the right costal margin. She had suffered from disseminated intravascular coagulation for which heparin and gabexate mesilate were given.<BR>Prednisolone and glucagon-insulin therapy were applied for acute hepatic insufficiency. However, she died from GI bleeding due to DIC on the 42nd day. The liver specimen showed many alcoholic hyalines with micronodular cirrhosis.<BR>Thirty-seven of the 111 patients (33.3%) with alcoholic hepatitis reported in the Japanese literature have died.<BR>Of these, reports of females are very few. The incidence of alcoholic hyaline was highest in patients who died of alcoholic hepatitis with liver cirrhosis.
社団法人日本肝臓学会の論文