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PHA and Con A responses, autologous mixed lymphocyte reaction (AMLR) and prostaglandin producing suppressor function (PPSF) in 6 cases of primary biliary cirrhosis (PBC), and the effect of corticosteroid on peripheral mononuclear cells and immune responses were studied in healthy volunteers. Although mitogen responses (S.I.) and PPSF were not abnormal, AMLR was significantly reduced in PBC. When methylprednisolone pulse therapy was tried in a case of PBC, clinical and laboratory findings and AMLR were improved and serum inhibitory factors were disappeared.<BR>AMLR and Con A response were reduced and PPSF increased after oral administration of 30mg of prednisolone to normal controls.<BR>These results suggest that the immunoregulatory function is impaired and methylprednisolone pulse therapy seems to improve clinical findings and abnormal immune responses in some of PBC. Corticosteroid seems to have some influence on PPSF.
社団法人日本肝臓学会の論文