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In order to study the clinical significance of Immunosuppressive acidic protein (IAP), whose property is its strong immunosuppressive activity in vivo and in vitro, in the liver disease, We have measured serum levels of IAP in various liver diseases and malignant disorders.<BR>Significantly higher levels (500μm/ml) of IAP were found in asymptomatic carrier with HBs-Ag than in normal subjects (p<0.001). On the other hand serum IAP levels in chronic liver diseases were lower than normal subjects, especially serum IAP levels in patients with cirrhosis of the liver were significantly lower than normal subjects (p<0.001). In malignant disorder, IAP levels in serum were further higher as compared with those of normal subjects.<BR>These results suggest that the role of IAP in liver disease was different from those in malignant disorders. Decreased production of IAP in chronic liver diseases may dependent on the function of macrophage, monocyte suppressor cell activity, and inhibitory effects of asymptomatic HBs-Ag carrier serum apperars to be in part IAP, which products by macrophage.
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