Clinical investigation on pituitary-gonadal axis in men with cirrhosis of the liver, with special reference to alcoholic cirrhosis of the liver.

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The pituitary gonadal axis in men with alcoholic liver cirrhosis was compared to that of nonalcoholic liver cirrhosis in age-mached and similar grade of liver damege in men. Basal Testosterone level was reduced (p<0.05) in alcoholics compared to non-alcoholics and normal controls. Basal Estrone (p<0.01) and Estradiol (p<0.05) levels and basal Gonadotropins (LH, FSH) concentrations (p<0.05) were increased in alcoholics compared to non-alcoholics and controls.<BR>Increased rate of Testosterone responsed to hCG in alcoholics was reduced compared to nonalcoholics, but reserved function of Leydig cell was enough remained, Gonadotropins (LH·FSH) and Testosterone responses to LH-RH (100μg·IV) was studied, an exaggerated response of LH and FSH to LH-RH was observed in alcoholics relative to non-alcoholics and normal controls, but increased rate of LH and Testosterone responsed to LH-RH were reduced in alcoholics compared to both groups.<BR>Based upon these result, we speculate that alcoholic liver cirrhosis have either normal pituitary responses to LH-RH or at most, a very moderate degree of impairment of only"LH", but chronic alcohol administration appears to "down regulate" of LH receptor in the testis.
社団法人日本肝臓学会の論文