DNA ploidy pattern and proliferating cell nuclear antigen(PCNA) labeling index in small hepatocellular carcinoma.

概要

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46 nodules of hepatocellular carcinoma (HCC) (<3cm in diameter) were studied by DNA ploidy pattern and PCNA immunohistochemical staining. The incidence of DNA aneuploidy in well differentiated HCC was significantly lower than in moderately or poorly differentiated HCC (p<0.05). PCNA labeling index (LI) corresponded to the degree of histologic differentiation (p<0.05). We classified 4 gross appearance according to The Liver Cancer Study Group of Japan: type 1; vaguely nodular type, type 2; single nodular type, type 3; single nodular type with extranodular growth, type 4; contiguous multinodular type. The incidence of DNA aneuploidy and the average PCNA LI was increasing according to this number (p<0.05). All HCCs of vaguely nodular type were diploidy and their PCNA LI showed very low value. We concluded that vaguely nodular type might be an early HCC only in view of tumor-related factors.
社団法人日本肝臓学会の論文