非抱合ビリルビンの代謝に関する臨床的研究

概要

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Following a single injection of bilirubin of 2 mg per kg body weight, the clearance of unconjugated bilirubin from the plasma was determined in 7 normal subjects as well as in 6 patients with chronic hepatitis, 5 with Gilbert's syndrome, 3 with hemolytic anemia, and 1 with polychlorinated biphenyls (PCB) poisoning. From the plasma disappearance curves, hepatic bilirubin uptake (a), reflux from liver to plasma (b) and elimination of bilirubin (m) were calculated by 2 exponential analysis.<BR>The normal values of (a), (b) and (m) were 0.0294±0.0032, 0.0139±0.0021 and 0.0145±0.0041, respectively and bilirubin retained at 4 hours was 9±3%. The plasma clearance of bilirubin was normal in patients with hemolytic anemia, but significantly impaired in patients with Gilbert's syndrome. In patients with chronic hepatitis (a) was significantly decreased and the retention was markedly increased. A patient with PCB poisoning showed an increase in (a). Phenobarbital treatment improved the clearance of unconjugated bilirubin from the plasma in patients with Gilbert's syndrome.
社団法人日本肝臓学会の論文