DIAGNOSTIC SIGNIFICANCE OF SERUM RIBONUCLEASE DETERMINATION IN THE PANCREATIC CANCER

概要

論文の詳細を見る
Serum ribonuclease (RNase) assay method, using polycytidylic aicd (Poly C) described by Reddi et al was modified, and its diagnostic significance was evaluated on various disease, especially on pancreatic cancer.Serum RNase was demonstrated that its source was pancreas, using Poly C as substrate. It had a pH optimum at 6.5 using 0.1M phosphate borate buffer. Strikingly abnormal elevations occured in the serum RNase of patients with pancreatic cancer. There were no significanct increase in the serum RNase level of patients with chronic pancreatitis. Average RNase values 15 normal persons, 17 patients with chronic pancreatitis, 13 patients with pancreatic cancer, and patients with miscellaneous cancer were 91, 124, 393, 168 units per ml, respectively. In patients with renal insufficiency marked elevation of serum RNase was also observed.On the clinical follow up study decrease of serum RNase levels was seen in patient showing good response to chemotherapy.From these results, serum RNase seems to be quite available diagnostic tool of pancreatic cancer in the presence of normal renal functions.
財団法人日本消化器病学会の論文