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In 33 patients with chronic pancreatitis (29 males, 4 females), basal levels of serum vitamin E were significantly reduced as compared with control subjects. The increments of serum vitamin E levels in the patients were significantly less than those in control subjects after oral administration of dl-alpha-tocopherol acetate (600mg). It is of further interest that a positive correlation between serum vitamin E level and exocrine pancreatic function was observed in the patients with chronic pancreatitis. Vitamin E absorption test by vitamin E administration into rat duodenum showed that the increments of serum vitamin E levels were slight in ligation of bile and/or pancreatic duct. On the other hand, serum lipid peroxide levels in patients with chronic pancreatitis showed a significant increase, and a significant negative correlation between serum vitamin E concentrations and lipid peroxide levels was demonstrated. Further, serum glutathione peroxidase (GSHPx) activities decreased in patients with chronic pancreatitis as well as in rats fed with the vitamin E deficient diet for a long period of time.In conclusion, malabsorption of vitamin E in patients with chronic pancreatitis was demonstrated. Less antioxidative activities due to the deficiency of vitamin E was assumed to be responsible for elevated lipid peroxidation. It was suggested that low activities of GSHPx, resolving lipid peroxide, were associated with vitamin E depletion.
財団法人日本消化器病学会の論文

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松本雅裕
九州大学医学部第3内科

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