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Serum trypin concentrations were measured by radioimmunoassay, using a commercial kit (Trypsin Radioimmunoassay Kit, CIS., Midorijugi). This kit-assay proved sensitive (minimum detectable concentration: 4.0 ng/ml), specific and highly reproducible.Serum trypsin values measured by this assay, significantly correlated with values assayed by another commercial kit (RIA-gnost Trypsin, Hoechst Japan), but the latter showed high values than the former (regression line: y=3.69x+42.4). And a distinct correlation between serum trypsin and elastase 1 (by RIA) values was also observed.In 28 normal subjects, mean serum trypsin value was 29.6±16.6 ng/ml (M±2SD), and increased serum trypsin concentrations were proved in all of 5 patients with acute pancreatitis. In 20 patients with chronic pancreatitis, 11 (55%) had concentrations above the normal range, and 7 (35%) had concentrations below the range. In pancreatic carcinoma. each 4 of 11 patients revealed a significant increase or decrease, respectively. In 14 patients with primary diabetes mellitus, only one patient showed a low concentration.In 26 patients with panccreatic diseases, 22 (84.6%) had abnormal levels of serum trypsin, whereas abnormal serum amylase concentrations were found in only 9 patients (34.6%).From these studies, the measurement of serum trypsin appears useful as a screening test for the diagnosis of pancreatic diseases.
財団法人日本消化器病学会の論文