CLINICAL SIGNIFICANCE OF QUANTITATIVE DETERMINATION OF LIPOPROTEIN X IN PATIENTS WITH CHOLESTASIS

概要

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To elucidate the clinical significance of quantitative determination of lipoprotein X (LP-X), LP-X concentration was determined in 44 patients with positive LP-X test. The LP-X concentrations in patients with extrahepatic biliary obstruction were usually higher than those in cases with intrahpatic cholestasis. All cases which showed LP-X levels higher than 400mg/dl had extrahpatic biliary obstruction. Correlation between the LP-X levels and cholesterol or alkaline phosphatase activities was highly significant in patients with extrahepatic biliary obstruction. In cases with intrahepatic cholestasis the LP-X levels were correlated well with alkaline phosphatase activities but lesser in depress with cholesterol concentrations. Of 44 LP-X positive cases, 5 cases were anicteric (bilirubin<2.0mg/dl), 6 cases were hypocholesterolemic (cholesterol<150mg/ml) and a case revealed normal alkaline phosphatase activity (ALP<100mU/ml). The quantitative analysis of LP-X concentration is a relatively simple procedure and revealed more significance for for the differential diagnosis of jaundiced patients than conventional biochemical analyses did.
財団法人日本消化器病学会の論文