CLINICAL STUDIES ON CEA OF DUODENAL JUICE IN PANCREATIC CANCER

概要

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The CEA levels in duodenal juice obtained after administration of Pancreozymin and Secretin were assayed by two step method of DINABOT RIA KIT.The CEA concentrations in duodenal juice were significantly high (P<0.001) in patients with pancreatic cancer than chronic pancreatitis and control subjects, especially in S3 fraction (40 minutes after Secretin injection).Average CEA values of pancreatic cancer, chronic pancreatitis and control subjects were 36.3±12.5, 23.0±8.6, and 16.3±6.4 ng/ml (M±SE), respectively. These results imply that CEA concentration in duodenal juice of S3 fraction may be a good indicator of the diagnosis of pancreatic cancer.When we compared the CEA levels of tumor extract with pancreatic cancer and normal pancreas, strikingly high levels of CEA in tumor were evident. The increased CEA levels in the tumor extract of pancreatic cancer may represent an increased CEA production by the proliferating tumor cells.
財団法人日本消化器病学会の論文