慢性肝炎の副腎皮質ホルモン療法に関する研究

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A controlled trial of corticosteroid treatment was performed in two randomly selected groups of patients with chronic active hepatitis during one year. The corticosteroid group contained 24 and the control group 20 patients. When compared with the control group, corticosteroid therapy caused a resolution of biochemical abnormalities in which the most significant finding was a marked decrease in serum gamma globulin and GOT. Galactose and unconjugated bilirubin clearances were significantly improved, but tolbutamide tolerance did not change. Histological features, such as liver cell degeneration, Kupffer cell mobilization and cell infiltration in portal tracts were also improved. It is concluded that a resolution of biochemical, metabolic and histological abnormalities after corticosteroid therapy may be attributable to decreased hepatic mesenchymal reaction and increased hepatic parenchymal cell function.
社団法人日本肝臓学会の論文