養殖アユにみられた抗酸菌性全身性多発性肉芽腫形成について

概要

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Histopathological studies were made on cultured ayu with systemic, multiple granuloma. Examined fish were collected from a farm in Tochigi Prefecture in 1989 and 1990. Macroscopically the disease was characterized by discoloration of the body, severely protruded eyes, and numerous small nodules on the surface of many organs as follows; liver, kidney, spleen, heart and intestine.<BR>Histology showed that these nodules were granulomas composed of mononuclear cells and surrounded by the thin connective tissue. Granulomas were also found in gill filaments and trunk muscles. Gram-positive, selener, long rods were abundantly detected in the granulomas. Some of these long rods were also stained positively with Ziehl-Neelsen method for acid-fast bacteria and methenamine silver-nitrate stain (Grocott's variation).<BR>From the results, the case of these fish was diagnosed as "systemic, multiple granuloma caused by acid-fast bacteria".
日本魚病学会の論文