Smoking, Alcohol, Sleep and Risk of Idiopathic Sudden Deafness: A Case-Control Study Using Pooled Controls.

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概要

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• Sudden deafness sometimes has an identifiable cause, but in most cases the cause is unknown (idiopathic sudden deafness). Vascular impairment has been proposed as an aetiological mechanism for this condition, but it is unclear whether traditional cardiovascular risk factors, such as smoking or alcohol intake, are associated with this condition. We accordingly investigated associations of idiopathic sudden deafness with smoking, alcohol intake and sleep duration in a case-control study. Cases were consecutive patients diagnosed with idiopathic sudden deafness between October 1996 and August 1998 at collaborating hospitals in Japan. Controls were obtained from a nationwide database of pooled controls, with matching for age, gender and residential district. Exposure variables were assessed from a self-administered questionnaire. Subgroup analyses were performed using audiometric subtypes of sudden deafness. Data were obtained for 164 cases and 20, 313 controls. Increased risks of idiopathic sudden deafness were observed among participants who consumed two or more units of alcohol per day (OR=1.90, 95% CI=1.12-3.21), and among participants who slept less than seven hours per night (OR=1.61, 95% CI=1.09-2.37). The direct association with alcohol intake was particularly strong for the participants with profound hearing loss. There was little evidence of an association with smoking. This study suggests that alcohol intake and short sleep duration might be risk factors for idiopathic sudden deafness. J Epidemiol, 2001 ; 11 : 81-86

• 日本疫学会の論文

著者

• KAWAMURA Takashi

  Kyoto University Center for Student Health

• Tanaka Heizo

  Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University

• Nakamura Mieko

  Department Of Community Health And Preventive Medicine Hamamatsu University School Of Medicine

• MORIOKA Seiji

  Koza Public Health Centre

• Yokoyama Tetsuji

  Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University

• Hashimoto Tsutomu

  Department Of Otorhinolaryngology Hamamatsu University School Of Medicine

• Hoshino Tomoyuki

  Department Of Oto-rhino-laryngology Hamamatsu Medical College

• Whitlock Gary

  Clinical Trials Research Unit University Of Auckland

• Ohno Yoshiyuki

  Department Of Pharmacy Kinjogakuin University

• Aoki Nobuo

  Department Of Hygiene Hamamatsu University School Of Medicine

• Nakashima Tsutomu

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Aoki Nobuo

  Department of Hygiene, Hamamatsu University School of Medicine

• OHNO YOSHIYUKI

  Department of Preventive Medicine, Nagoya University School of Medicine

• YOKOYAMA Tetsuji

  Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University

• AOKI Nobuo

  Department of Epidemiology, National Cardiovascular Center

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