FXYD6, a Na,K-ATPase Regulator, Is Expressed in Type II Taste Cells
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概要
- 論文の詳細を見る
Taste buds contain three types of taste cells. Each type can respond to taste stimulation, and type II and III taste cells are electrically excitable. However, there are differences between the properties of type II and III taste cells. In this study, we found that Fxyd6, an Na,K-ATPase regulator gene, is expressed in type II taste cells in the taste buds of mice. Double-labeled in situ hybridization analysis showed that Fxyd6 was coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the sweet, bitter, and umami taste signal transduction pathways and that it was specifically expressed in type II taste cells. We also found that taste cells frequently coexpressed Fxyd6 and Na,K-ATPase β1. These results indicate the presence of an inherent mechanism that regulated transmembrane Na+ dynamics in type II taste cells.
著者
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Kanda Tomomasa
Research Laboratories for Fundamental Technology of Food, Asahi Breweries, Ltd.
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CARNINCI Piero
RIKEN, Tsukuba
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Kusakabe Yuko
National Food Research Institute
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Kawai Jun
Riken Omics Science Center
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Hino Akihiro
National Food Research Institute Ministry Of Agriculture Forestry And Fisheries
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Hayashizaki Yoshihide
Riken Omics Science Center
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SHINDO Yoichiro
Research Laboratories for Health and Gustatory Science, Asahi Breweries, Ltd.
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MORISHITA Kana
National Food Research Institute, National Agriculture and Food Research Organization
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KOTAKE Eiichi
Research Laboratories for Health and Gustatory Science, Asahi Breweries, Ltd.
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MIURA Hirohito
Kagoshima University Graduate School of Medical and Dental Sciences
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