MESとBN.MES-Cyba[mes]コンジェニック系ラットにおける好酸球増多症に関する系統差を規定する遺伝子は第9,5,および1番染色体上に存在する

スポンサーリンク

概要

• 論文の詳細を見る

• The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia due to the mutant Cybames gene. In contrast, BN.MES-Cybames congenic rats, in which the mutant Cybames gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. However, the congenic rats manifest focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. To elucidate the genetic basis for the strain differences, (MES × BN.MES-Cybames)F2 rats were bred, and genetic analyses of phenotypes for eosinophilia were performed. Blood and bone marrow eosinophil levels in the F2 rats showed broad distributions, suggesting that the traits were under the influence of multiple genes. Genetic association studies revealed that BN-derived marker loci on chromosomes 9 and 5 were responsible for the increase in eosinophil level in the bone marrow, decrease in blood eosinophil level, and the induction of focal necrosis with eosinophilic infiltration in the liver. The BN-derived allele of the marker gene on chromosome 1 was responsible for the decrease of both bone marrow and blood eosinophil levels. These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cybames on these chromosomes, and form the basis for positional cloning studies of the genes. These studies will advance the understanding of the mechanisms involved in eosinophil mobilization from the bone marrow and recruitment to the organs.

著者

• MORI Masayuki

  Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o

• Mori Masayuki

  Dep. Of Aging Biology Inst. On Aging And Adaptation Shinshu Univ. Graduate School Of Medicine

• HIGUCHI Keiichi

  Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o

• MATSUMOTO Kiyoshi

  Division of Toxicology, National Institute of Hygienic Sciences

• Mori Masayuki

  Department Of Aging Angiology Research Cnter On Aging And Adaptation Shinshu University School Of Me

• TOMOZAWA Hiroshi

  Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinsh

• NISHIO Ayako

  Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinsh

• Higuchi Keiichi

  Department Of Aging Angiology Research Center For Aging And Adaptation Shinshu University

• Matsumoto Kiyoshi

  Division Of Food Biotechnology Department Of Bioscience And Biotechnology Faculty Of Agriculture Gra

• Higuchi Keiichi

  Department Of Aging Biology Institute On Aging And Adaptation Shinshu University Graduate School Of

関連論文

• Senile Systemic Amyloidosis in an Aged Savannah Monkey (Cercopithecus aethiops) with Tenosynovial Degeneration
• A New Beige Mutant Rat ACI/N-Lyst^bg-Kyo
• Establishment of a Set of Combined Immunodeficient DA/Slc-Foxn1^ Lyst^ Congenic Rat Strains
• The Rat Lysosomal Trafficking Regulator (Lyst) Gene is Mapped on the Telomeric Region of Chromosome 17
• An Allele-Specific Genotyping Method for Rat Lyst (Lysosomal Trafficking Regulator) Gene
• SAM系マウスはAbcb1a遺伝子に自然突然変異をもつ
• Immunohistochemical study with anti-advanced glycation end-products antibody in murine amyloidosis
• Quantitative Trait Locus Analysis of Serum Insulin, Triglyceride, Total Cholesterol and Phospholipid Levels in the (SM/J×A/J)F_2 Mice
• Quantitative Trait Loci for Body Weight in the Intercross between SM/J and A/J Mice
• Distribution of Body Weight, Blood Insulin and Lipid Levels in the SMXA Recombinant Inbred Strains and the QTL Analysis
• SHORT-TERM TOXICITY STUDY OF 4-DIMETHYLAMINOAZOBENZENE IN MARMOSETS
• ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS(4-METHYL-6-TERT-BUTYLPHENOL) IN RATS
• Absorption of Val-Tyr with in Vitro Angiotensin I-Converting Enzyme Inhibitory Activity into the Circulating Blood System of Mild Hypertensive Subjects
• Evaluation of α-Glucosidase Inhibition by Using an Immobilized Assay System
• MESとBN.MES-Cyba[mes]コンジェニック系ラットにおける好酸球増多症に関する系統差を規定する遺伝子は第9,5,および1番染色体上に存在する
• EFFECT OF MITOMYCIN C ON BONE MARROW CELLS IN MICE
• Partial Purification and Demonstration of Anti-tumor Activity of High Molecular Weight DNA-binding Protein (HMDBP) in Ascitic Fluid of Mice with Meth-A Ascites Fibrosarcoma
• 遺伝性膵炎モデルであるWBN/Kob系ラットは第7染色体上のPdwk1領域に特殊なハプロタイプを有する
• Molecular Cloning and Characterization of a New Neuron-Specific Homologue of Rat Polypyrimidine Tract Binding Protein^1
• 老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
• BN.MES-Cyba[mes]コンジェニック系ラットは血中の好酸球増多を発症することなく肝臓への好酸球浸潤による壊死像を呈する
• Evaluation of Short-term Myelotoxicity Study in Dietary Reduced Rats
• Importance of Starting Age for Myelotoxicity Study in Dietary Restricted Rats
• Evaluation of Myelotoxicity in Dietary Restricted Rats
• Quantitative trait locus on chromosome X affects bone loss after maturation in mice
• ABCB1Aの機能障害はSAM系マウスのデキストラン硫酸による誘発大腸炎に対する感受性には大きく影響しない
• Intercalibration of the Acridine Orange Direct Count Method of Aquatic Bacteria
• Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II
• Electrochemical Measurement of Yeast Cell Density and Vitality Using 2,3,5-Trimethyll, 4-benzoquinone and Effect of Ethanol on the Metabolism of Quinone by Yeast Cells
• Functional Polymorphisms of the Lss and Fdft1 Genes in Laboratory Rats
• W1-2 USE OF INSTRUMENTS FOR GENERAL TOXICOLOGY TESTING.
• Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba^ Rats Are on Chromosomes 9, 5, and 1
• 老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
• Spectrophotometric Assay of Yeast Vitality Using 2, 3, 5, 6 - Tetramethyl - 1,4 - benzoquinone and Tetrazolium Salts
• Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
• DNA microarray analysis of transcriptional responses of rats housed on solid and grid cage flooring
• A Third Locus for Eosinophilia on Chromosome 1 of the MES Rats

もっと見る 閉じる

スポンサーリンク