老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である

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概要

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• This study determined pathogenicity of an A11181G mtDNA mutation found in a senescence-accelerated mouse strain, SAMP8. The mutation was at a highly conserved site of the mt-Nd4 gene, which encodes one of the respiratory complex I subunits. The young SAMP8 expressed reduced complex I activity, which is controlled by both nuclear and mitochondrial DNA (mtDNA). To exclude the nuclear effects, we isolated transmitochondrial cybrids that share the same nuclear background, but possess mtDNA with or without the mutation. The cybrids showed normal respiratory function irrespective of whether their mtDNA possessed the mutation or not, suggesting that the A11181G mutation is not responsible for respiration defects found in SAMP8.

• 2011-07-01

著者

• Nakada Kazuto

  筑波大学 大学院生命環境科学研究科

• Mori Masayuki

  Department Of Aging Angiology Research Cnter On Aging And Adaptation Shinshu University School Of Me

• Hayashi Jun-ichi

  Graduate School Of Life And Environmental Sciences University Of Tsukuba

• Nakada Kazuto

  Graduate School Of Life And Environmental Sciences Univ. Of Tsukuba

• IMANISHI Hirotake

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• YOKOTA Mutsumi

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• SHIMIZU Akinori

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• Shimizu Akinori

  Graduate School Of Life And Environmental Sciences University Of Tsukuba

• Mori Masayuki

  Department Of Aging Angiology Research Center On Aging And Adaptation Shinshu University School Of M

• Imanishi Hirotake

  Graduate School Of Life And Environmental Sciences University Of Tsukuba

• Yokota Mutsumi

  Graduate School Of Life And Environmental Sciences University Of Tsukuba

• 今西 泰赳

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• 横田 睦美

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• 森 政之

  Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine

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