ABCB1Aの機能障害はSAM系マウスのデキストラン硫酸による誘発大腸炎に対する感受性には大きく影響しない
スポンサーリンク
概要
- 論文の詳細を見る
Genetic alterations in the gene for ATP-binding cassette, sub-family B (MDR/TAP), member 1A (ABCB1A) determine susceptibility to colitis in mice and humans. We investigated the influence of ABCB1A dysfunction on susceptibility to dextran sulfate sodium (DSS)-induced colitis by using Senescence-Accelerated Mouse (SAM) strains with a loss-of-function mutation in the Abcb1a gene (SAMR1, SAMP1, and SAMP6). Susceptibility to DSS colitis was different among SAM strains but on the whole was not different from other mouse strains with normal ABCB1A function. Thus, genetic factors other than loss of ABCB1A are more crucial in determining susceptibility to DSS colitis in SAM strains.
- Japanese Association for Laboratory Animal Scienceの論文
著者
-
Mori Masayuki
Dep. Of Aging Biology Inst. On Aging And Adaptation Shinshu Univ. Graduate School Of Medicine
-
Mori Masayuki
Department Of Aging Angiology Research Cnter On Aging And Adaptation Shinshu University School Of Me
-
FU Xiaoying
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o
-
ZHANG Guohong
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o
-
Higuchi Keiichi
Department Of Aging Angiology Research Center For Aging And Adaptation Shinshu University
-
TAKEDA Toshio
The Council for SAM Research
-
Higuchi Keiichi
Department Of Aging Biology Institute On Aging And Adaptation Shinshu University Graduate School Of
-
Mori Masayuki
Department Of Aging Biology Institute On Aging And Adaptation Shinshu University Graduate School Of
-
Mori Masayuki
Department Of Aging Angiology Research Center On Aging And Adaptation Shinshu University School Of M
-
張 国紅
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine
-
付 笑影
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine
-
竹田 俊男
The Council for SAM Research
関連論文
- A New Beige Mutant Rat ACI/N-Lyst^bg-Kyo
- Establishment of a Set of Combined Immunodeficient DA/Slc-Foxn1^ Lyst^ Congenic Rat Strains
- The Rat Lysosomal Trafficking Regulator (Lyst) Gene is Mapped on the Telomeric Region of Chromosome 17
- An Allele-Specific Genotyping Method for Rat Lyst (Lysosomal Trafficking Regulator) Gene
- SAM系マウスはAbcb1a遺伝子に自然突然変異をもつ
- Immunohistochemical study with anti-advanced glycation end-products antibody in murine amyloidosis
- Quantitative Trait Locus Analysis of Serum Insulin, Triglyceride, Total Cholesterol and Phospholipid Levels in the (SM/J×A/J)F_2 Mice
- Quantitative Trait Loci for Body Weight in the Intercross between SM/J and A/J Mice
- Distribution of Body Weight, Blood Insulin and Lipid Levels in the SMXA Recombinant Inbred Strains and the QTL Analysis
- MESとBN.MES-Cyba[mes]コンジェニック系ラットにおける好酸球増多症に関する系統差を規定する遺伝子は第9,5,および1番染色体上に存在する
- Partial Purification and Demonstration of Anti-tumor Activity of High Molecular Weight DNA-binding Protein (HMDBP) in Ascitic Fluid of Mice with Meth-A Ascites Fibrosarcoma
- 遺伝性膵炎モデルであるWBN/Kob系ラットは第7染色体上のPdwk1領域に特殊なハプロタイプを有する
- Molecular Cloning and Characterization of a New Neuron-Specific Homologue of Rat Polypyrimidine Tract Binding Protein^1
- 老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
- BN.MES-Cyba[mes]コンジェニック系ラットは血中の好酸球増多を発症することなく肝臓への好酸球浸潤による壊死像を呈する
- Quantitative trait locus on chromosome X affects bone loss after maturation in mice
- ABCB1Aの機能障害はSAM系マウスのデキストラン硫酸による誘発大腸炎に対する感受性には大きく影響しない
- Intercalibration of the Acridine Orange Direct Count Method of Aquatic Bacteria
- Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II
- Interlamellar Spacing of Pearlite in a Near-eutectoid Fe-C Alloy Measured by Serial Sectioning
- Functional Polymorphisms of the Lss and Fdft1 Genes in Laboratory Rats
- Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba^ Rats Are on Chromosomes 9, 5, and 1
- 老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
- Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
- A Third Locus for Eosinophilia on Chromosome 1 of the MES Rats