遺伝性膵炎モデルであるWBN/Kob系ラットは第7染色体上のPdwk1領域に特殊なハプロタイプを有する
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概要
- 論文の詳細を見る
The WBN/Kob rat strain is a hereditary animal model of chronic pancreatitis and diabetes mellitus. The major WBN/Kob loci for pancreatitis (Pdwk1 and Pdwk2) are located on chromosomes 7 and X, respectively. In this study, polymorphisms were sought for candidate genes in the Pdwk1 and Pdwk2 regions. Nucleotide polymorphisms were found in 14 candidate genes examined in the Pdwk1 region. These polymorphisms were not associated with functional changes, and hence were unlikely to be a cause of pancreatitis. Seven nucleotide polymorphisms in three candidate genes, Rac2, Grap2, and Xpnpep3, located within a 3.3-Mb region were not found in 14 other inbred rat strains. These results suggest that WBN/Kob has a unique haplotype block in the chromosomal region contatining Pdwk1.
- 社団法人 日本実験動物学会の論文
著者
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Chen Lei
Department Of Chemistry Graduate School Of Science Tokyo Metropolitan University
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MORI Masayuki
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o
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Mori Masayuki
Dep. Of Aging Biology Inst. On Aging And Adaptation Shinshu Univ. Graduate School Of Medicine
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HIGUCHI Keiichi
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o
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森 政之
信州大学ヒト環境科学研究支援センター 生命科学分野動物実験部門
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Mori Masayuki
Department Of Aging Angiology Research Cnter On Aging And Adaptation Shinshu University School Of Me
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FU Xiaoying
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o
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ZHANG Guohong
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School o
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Higuchi Keiichi
Department Of Aging Angiology Research Center For Aging And Adaptation Shinshu University
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Higuchi Keiichi
Department Of Aging Biology Institute On Aging And Adaptation Shinshu University Graduate School Of
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Mori Masayuki
Department Of Aging Biology Institute On Aging And Adaptation Shinshu University Graduate School Of
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Mori Masayuki
Department Of Aging Angiology Research Center On Aging And Adaptation Shinshu University School Of M
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森 政之
Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine
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Mori Masayuki
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine
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CHEN Lei
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine
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付 笑影
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine
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陳 磊
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine
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