老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
スポンサーリンク
概要
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This study determined pathogenicity of an A11181G mtDNA mutation found in a senescence-accelerated mouse strain, SAMP8. The mutation was at a highly conserved site of the mt-Nd4 gene, which encodes one of the respiratory complex I subunits. The young SAMP8 expressed reduced complex I activity, which is controlled by both nuclear and mitochondrial DNA (mtDNA). To exclude the nuclear effects, we isolated transmitochondrial cybrids that share the same nuclear background, but possess mtDNA with or without the mutation. The cybrids showed normal respiratory function irrespective of whether their mtDNA possessed the mutation or not, suggesting that the A11181G mutation is not responsible for respiration defects found in SAMP8.
著者
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Mori Masayuki
Department Of Aging Angiology Research Cnter On Aging And Adaptation Shinshu University School Of Me
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Hayashi Jun-ichi
Graduate School Of Life And Environmental Sciences University Of Tsukuba
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Nakada Kazuto
Graduate School Of Life And Environmental Sciences Univ. Of Tsukuba
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IMANISHI Hirotake
Graduate School of Life and Environmental Sciences, University of Tsukuba
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YOKOTA Mutsumi
Graduate School of Life and Environmental Sciences, University of Tsukuba
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SHIMIZU Akinori
Graduate School of Life and Environmental Sciences, University of Tsukuba
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