mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析

スポンサーリンク

概要

• 論文の詳細を見る

• The most common approach to analyzing the static morphology of mitochondria involves staining by antibodies or fluorescent dyes specific for mitochondrial components. In this study, we present a new approach using transgenic (Tg) mice, mtGFP-Tg mice, which exclusively express EGFP in the mitochondrial matrix. This Tg strain enables the rapid and easy observation of mitochondria in many kinds of tissues of interest. Recently, many reports have indicated that mitochondrial abnormalities and disease phenotypes are closely associated. mtGFP-Tg mice will be very useful in demonstrating this association, via the use of hybrids of mtGFP-Tg mice and well-established model mice for human diseases.

• 社団法人　日本実験動物学会の論文
• 2010-01-01

著者

• 設楽 浩志

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• 島貫 碧

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• 林 純一

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• YONEKAWA Hiromichi

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• SHITARA Hiroshi

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• SHIMANUKI Midori

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• HAYASHI Jun-Ichi

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• Yonekawa Hiromichi

  Laboratory Of Mouse Models For Human Heritable Diseases The Tokyo Metropolitan Institute Of Medical

• Shitara Hiroshi

  Laboratory Of Mouse Models For Human Heritable Diseases The Tokyo Metropolitan Institute Of Medical

• Shimanuki Midori

  Laboratory Of Mouse Models For Human Heritable Diseases The Tokyo Metropolitan Institute Of Medical

• Hayashi Jun-ichi

  Graduate School Of Life And Environmental Sciences University Of Tsukuba

関連論文

• mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析
• Expression of the Apoptosis-Mediator Fas Is Enhanced by Dysfunctional Mitochondria
• Expression of the Apoptosis-Mediator Fas Is Enhanced by Dysfunctonal Mitochondria
• mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析
• 老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
• Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model
• ミトコンドリアゲノム変異導入マウス
• 老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である
• ミトコンドリアゲノム変異導入マウス
• Effects of H2O2 Treatment of Mouse B82 Cells on mtDNA Amounts and Respiratory Function

スポンサーリンク