mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析

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概要

• 論文の詳細を見る

• The most common approach to analyzing the static morphology of mitochondria involves staining by antibodies or fluorescent dyes specific for mitochondrial components. In this study, we present a new approach using transgenic (Tg) mice, mtGFP-Tg mice, which exclusively express EGFP in the mitochondrial matrix. This Tg strain enables the rapid and easy observation of mitochondria in many kinds of tissues of interest. Recently, many reports have indicated that mitochondrial abnormalities and disease phenotypes are closely associated. mtGFP-Tg mice will be very useful in demonstrating this association, via the use of hybrids of mtGFP-Tg mice and well-established model mice for human diseases.

• 社団法人　日本実験動物学会の論文

著者

• 設楽 浩志

  東京農業大学 生物産業学部

• 設楽 浩志

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• 島貫 碧

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• 林 純一

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• YONEKAWA Hiromichi

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• SHITARA Hiroshi

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• SHIMANUKI Midori

  Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical

• HAYASHI Jun-Ichi

  Graduate School of Life and Environmental Sciences, University of Tsukuba

関連論文

• mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析
• mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析
• ミトコンドリアゲノム変異導入マウス

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