Safety Test and Field Study of an Oil-Adjuvanted H5N1 Avian Influenza Inactivated Vaccine
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概要
- 論文の詳細を見る
We previously reported the development of an inactivated oil-adjuvanted avian influenza vaccine using an apathogenic H5N1 strain of the same-lineage as the Eurasian lineage viruses currently epidemic in Asia. In this study, we confirmed the safety and evaluated the efficacy of this vaccine in layer chicken farms by field trials. No problematic adverse reactions occurred in the safety test. In addition, no adverse effects were observed in the field trial, and the antibody titer exceeded a protective level [hemagglutination inhibition (HI) antibody titer of 16] at 3 weeks after a single injection. Based on the above findings, this vaccine was confirmed to be safe and induced a protective level of antibody titer by single injection in farms.
- 社団法人 日本獣医学会の論文
著者
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Sakamoto Ryuichi
Chemo‐sero‐therapeutic Res. Inst. Kikuchi
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Imamura Takashi
Division 2, Second Research Department, The Chemo-Sero-Therapeutic Research Institute
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Sakamoto Ryuichi
Division 2, Second Research Department, The Chemo-Sero-Therapeutic Research Institute
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Sasaki Takashi
Avian Biologics Department, Kyoto Biken Laboratories, Inc.
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KOKUMAI Norihide
Avian Biologics Department, Kyoto Biken Laboratories, Inc.
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OHGITANI Toshiaki
Avian Biologics Department, Kyoto Biken Laboratories, Inc.
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SAWATA Akira
Kitasato Institute Research Center for Biologicals
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LIN Zhifeng
Research Department, Nippon Institute for Biological Science
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SAKAGUCHI Masashi
Division 2, Second Research Department, The Chemo-Sero-Therapeutic Research Institute
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Sawata Akira
Kitasato Inst. Res. Center For Biologicals Kitamoto
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Takashima Ikuo
Hokkaido Univ. Hokkaido Jpn
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