コロニー形成試験による圧電材料の細胞毒性評価

概要

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Biocompatible piezoelectric materials are becoming increasingly important for actuators and sensors in medical devices. In this paper, we highlighted on some perovskite oxides MgSiO3, CaSiO3, CaTiO3 and CaZrO3 which are biocompatible piezoelectric materials discovered by first-principles calculation in our previous studies. In order to verify their biocompatibility, the cytotoxicity of their isomeric oxides with the same components was examined as comparing with typical perovskite oxides Pb(Zr, Ti)O3 and BaTiO3. The fibroblast (L929) cells were cultured during 7 days and the effect of materials was evaluated by the half maximal inhibitory concentration (IC50). As a result, the colony formation assay indicated that BaTiO3, CaTiO3, MgSiO3 and CaZrO3 has the higher IC50 values. On the other hand, CaSiO3 and Pb(Zr,Ti)O3 shows the strong toxicity. The obtained IC50 values had a good correlation with the proliferation ratio in our previous studies.