PS5 コロニー形成試験による無鉛圧電材料の細胞毒性評価(フェロー賞対象ポスターセッション)

概要

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Biocompatible piezoeleciric materials are becoming increasingly important for actuators and sensors in medical devices. In this paper, we highlighted on some perovskite-type oxides MgSiO_3, CaSnO_3, and MgTiO_3 which were discovered through first-principles calculation in our previous studies to fabricate new Irad-free biocompatible piezoelectric materials. In order to verify their biocompatibility, the cytotoxicity of isotopic oxides with the same components was examined as comparing with typical perovskite-type oxides KNbO_3 and LiMbO_3. The fibroblast (L929) cells were cultured during 7 days and the effect of materials was evaluated by the half maximal inhibitory concentration (IC50). As a result, it was recognized that MgSiO_3 and CaSnO_3 has the higher biocompatibility. On the other hand, LiNbO_3 shows the strong toxicity.
2010-10-09