細胞毒性実験による圧電材料の生体適合性評価

概要

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Biocompatible piezoelectric materials are becoming increasingly important for actuators and sensors in medical devices. In this paper, we highlighted on some perovskite-type oxides MgSiO3, CaSiO3 and CaTiO3 of biocompatible piezoelectric materials discovered by first-principles calculation in our previous studies. In order to verify their biocompatibility, the cytotoxicity of similar oxides with the same components was examined as comparing with typical perovskite-type oxides Pb(Zr, Ti)O3 and BaTiO3. The fibroblast (L929) cells were cultured during 7days and the effect of materials was evaluated by relative proliferation ratio and doubling time. As a result, it was recognized that MgSiO3 and CaTiO3 has the higher biocompatibility. On the other hand, CaSiO3 and Pb(Zr, Ti)O3 shows the strong toxicity and they can't be applied to medical devices.