酵素固定化バイオセンサを含む携帯型自動血液吸引Bio-MEMSの開発(2006年度学部等研究教育補助金採択者報告)

概要

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Medical devices such as a micropump to extract blood through a needle have a structure in which needle and pump are mutually separated, hence, it is not easy to make the micropump including the microneedle smaller. In this study, the tube type micropump installed with set ring type PZT actuator up on a silicone tube was proposed. The flow function demonstrated by the tube type micropump was evaluated and the flow rates were increased 2.78% and decreased 1.79%, thus confirming the control of the flow rate. Furthermore, due to the need for a small blood sugar level monitor for the Bio-MEMS, the two electrodes method based on the effect of hydrogen peroxide caused by the reaction of glucose oxidase was developed, which has 5 % target measuring resolution for the blood sugar level monitor. It was confirmed that the electron flowed from the aluminum electrode to the platinum electrode by the influence of hydrogen peroxide from the red discoloration seen at the platinum electrode side using phenolphthalein solution. Moreover, the system demonstrated less than 5 % measuring resolution.