Angiotensin I-Converting Enzyme Inhibitory Action of Fish Sauce.
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概要
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The angiotensin I-converting enzyme (ACE) inhibitory activity of fish sauce, the product with the strongest ACE inhibitory activity among liquid fermented foods, was fractionated into 2 fractions with ethanol treatment. The major part of the inhibitory substance was contained in the supernatant fraction (S-fraction) and its intraperitoneal administration had a hypotensive effect on spontaneously hypertensive rat (SHR). By octadecyl-silane column chromatography and two successive kinds of gel filtration, the inhibitory activity of the S-fraction was further separated into several fractions indicating that the strong inhibitory activity of the fish sauce is caused by a combined action of various kinds of inhibitory substances present. From the fraction with the lowest 50% inhibition concentration IC<SUB>50</SUB> value, three kinds of dipeptides, glycyl-tryptophan, isoleucyl-tryptophan and valyl-tryptophan, were isolated as the ACE inhibitory compounds. Oral administration of these peptides to SHR showed a hypotensive effect.
- 社団法人 日本食品科学工学会の論文
著者
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Yanagida Fujiharu
Department Of Fermentation Science Faculty Of Applied Bioscience Tokyo University Of Agriculture
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Matsumoto Eiko
Department of Brewing and Fermentation, Tokyo University of Agriculture
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Koizumi Yukimichi
Department Of Fermentation Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Yasuhara Tadashi
Department Of Nutrition Junior College Of Tokyo University Of Agriculture
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Kawamura Yukio
National Food Res. Inst. Ibaraki Jpn
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OKAMOTO (KAINUMA)
Department of Brewing and Fermentation, Tokyo University of Agriculture
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IWASHITA Atsuko
Hokkaido Tokachi Area Regional Food Processing Technology Center
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KAWAMURA Yukio
National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries
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YANAGIDA Fujiharu
Department of Brewing and Fermentation, Tokyo University of Agriculture
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YASUHARA Tadashi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo
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