Human H5N2 Avian Influenza Infection in Japan and the FactorsAssociated with High H5N2-Neutralizing Antibody Titer

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概要

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• Background: H5N2 avian influenza virus infection of humans has not been reported thus far. The first H5N2 avian influenza infection of poultry in Japan occurred in Ibaraki. Methods: The subjects were workers at 35 chicken farms in Ibaraki Prefecture, where the H5N2 virus or antibody was isolated from chickens. None of the subjects exhibited influenza symptoms. The H5N2-neutralizing antibody titers of the first and second paired sera samples were compared. To investigate the possible factors for this increase, the H5N2-neutralizing antibody titer (1:40 or more) was calculated for the second samples. A logistic regression analysis was performed to examine the association of these factors with H5N2-neutralizing antibody positivity. Results: We performed Wilcoxon matched-pairs signed-ranked test on data collected from 257 subjects, and determined that the H5N2 antibody titers of the second paired sera samples were significantly higher than those of the first samples (P < 0.001). The H5N2 antibody titers of paired sera of 13 subjects without a history of seasonal influenza vaccination within the previous 12 months increased 4-fold or more. The percentage of antibody positivity was 32% for subjects with a history of seasonal influenza vaccination (28% of all subjects) and 13% for those without a history of the same. The adjusted odds ratio of H5N2-neutralizing antibody positivity was 4.6 (95% confidence interval: 1.6-13.7) for those aged over 40 and 3.1 (95% confidence interval: 1.6-6.1) for those with a history of seasonal influenza vaccination within the previous 12 months. Conclusion: The results suggest that this may have been the first avian influenza H5N2 infection of poultry to affect humans. A history of seasonal influenza vaccination might be associated with H5N2-neutralizing antibody positivity.

著者

• Doi Mikio

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Nakamura Yosikazu

  Department Of Health Science Division Of Epidemiology And Community Health Jichi Medical School

• YAMAZAKI Yoshinao

  Ibaraki Prefectural Institute of Public Health

• Yasui Yoshinori

  Infectious Disease Surveillance Center National Institute Of Infectious Diseases

• Izumi Youko

  Department Of Health And Welfare Ibaraki Prefectural Government

• Nakashima Kazutoshi

  Infectious Disease Surveillance Center National Institute Of Infectious Diseases

• Kawada Yuichi

  Department Of Health And Welfare Ibaraki Prefectural Government

• Ogata Tsuyoshi

  Chikusei Health Center Ibaraki Prefectural Government

• Nagata Noriko

  Department Of Chemical And Biological Sciences Japan Women's University

• Itamura Shigeyuki

  Department Of Virology National Institute Of Infectious Diseases

• Fujieda Takashi

  Department Of Health And Welfare Ibaraki Prefectural Government

• Okabe Nobuhiko

  Infectious Disease Surveillance Center National Institute Of Infectious Disease

• Tashiro Masato

  Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences

• Fujieda Takashi

  Department of Health and Welfare, Ibaraki Prefectural Government.

• Itamura Shigeyuki

  Department of Virology, National Institute of Infectious Diseases.

• Nakamura Yosikazu

  Department of Public Health, Jichi Medical University.

• Doi Mikio

  Department of Health and Welfare, Ibaraki Prefectural Government.

• Okabe Nobuhiko

  Infectious Disease Surveillance Center, National Institute of Infectious Diseases.

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