Association Between Stroke and Metabolic Syndrome in a Japanese Population : Jichi Medical School (JMS) Cohort Study

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概要

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• Background: Metabolic syndrome increases the morbidity and mortality of cardiovascular diseases. However, few studies have examined the association between the incidence of stroke and metabolic syndrome, as defined by Japanese criteria. The aim of this study was to identify the association between stroke and metabolic syndrome, as defined by criteria used in Japan.Methods: A total of 2205 subjects (920 men and 1285 women) were examined between 1992 and 1995 as part of the Jichi Medical School Cohort Study. Metabolic syndrome was defined using the Japanese criteria. Medical records, computed tomography, and magnetic resonance imaging were used to diagnose stroke. The Cox proportional-hazards model was used to analyze the association between metabolic syndrome and incident stroke.Results: The prevalence of metabolic syndrome at baseline was 9.0% in men and 1.7% in women. There were 96 incident strokes during an 11.2-year follow-up period, 14 of which occurred in subjects with metabolic syndrome. Among subjects with metabolic syndrome, the age-adjusted hazard ratio (95% confidence interval) for stroke was 1.93 (0.94–3.96) in men and 6.85 (2.68–17.47) in women. After adjusting for age, smoking status, and alcohol drinking status, the hazard ratio was 1.89 (0.88–4.08) in men and 7.24 (2.82–18.58) in women. Age-adjusted hazard ratios associated with having 2 or more components of metabolic syndrome, with and without central obesity, were 2.93 (1.21–7.08) and 3.20 (1.23–8.31) in men and 1.75 (0.69–4.44) and 8.64 (2.82–28.03) in women, respectively.Conclusions: The presence of metabolic syndrome, as defined by Japanese criteria, increases the risk of stroke; this effect was highly significant among women.

• 2010-01-01

著者

• Nakamura Yosikazu

  Department of Public Health, Jichi Medical University

• Kitamura K

  Department Of Geriatric Medicine Ehime University Graduate School Of Medicine

• Kikuchi Kenjiro

  Second Department Of Internal Medicine Sapporo Medical College

• ISHIKAWA Shizukiyo

  Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University

• KAYABA Kazunori

  School of Health and Social Services, Saitama Prefectural University

• GOTOH Tadao

  Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University

• KAJII Eiji

  Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University

• KIMURA Kenjiro

  St. Marianna University School of Medicine

• Komamura Kazuo

  Department Of Cardiovascular Dynamics Research Institute National Cardiovascular Center

• Kayaba Kazunori

  Department Of Cardiology Jichi Medical University

• Kario Kazuomi

  自治医科大学 地域医療学

• Nakamura Y

  Department Of Public Health Jichi Medical University

• Kitamura K

  Division Of Circulatory And Body Fluid Regulation Faculty Of Medicine Department Of Internal Medicin

• NIWA Yasunori

  Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University

• Kurose K

  Department Of Vascular Physiology Research Institute National Cardiovascular Center

• Gotoh Tadao

  Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University

• Gotoh Tadao

  自治医科大学地域医療学センター 地域医療学

• Gotoh Tadao

  自治医科大学地域医療学センター 地域医療学部門

• Gotoh Tadao

  自治医科大学 公衆衛生学

• Kawamura Keishiro

  The Third Division Internal Medicine Osaka College

• Nakamura Yosikazu

  自治医科大学地域医療学センター 地域医療学

• Nakamura Yosikazu

  千代田区千代田保健所

• Kayaba Kazunori

  自治医科大学 地域医療学

• Gotoh Tadao

  自治医科大学 地域医療学

• Ishikawa Shizukiyo

  Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University

• Ishikawa Shizukiyo

  自治医科大学 医学部循環器内科学

• Ishikawa Shizukiyo

  自治医科大学地域医療学センター

• Ishikawa Shizukiyo

  自治医科大学地域医療学センター 地域医療学部門

• Kajii Eiji

  Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University

• Kajii Eiji

  自治医科大学 地域医療学

• Niwa Yasunori

  Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University

• Kimura Kazuo

  Division Of Cardiology Yokohama City University Medical Center

• Ishikawa Suzukiyo

  南郷村国民健康保険病院

• Kitamura K

  Faculty Of Medicine Department Of Internal Medicine Division Of Circulatory And Body Fluid Regulatio

• Kohara Katsuhiko

  Department Of Geriatric Medicine Ehime Unviersity School Of Medicine

• Kikuchi Kan

  Department Of Blood Purification Kidney Center Tokyo Women's Medical University

• Kammatsuse Katsuo

  Nihon University

• Nakamura Yosikazu

  Department Of Health Science Division Of Epidemiology And Community Health Jichi Medical School

• Kodama Kazuhisa

  Internal Medicine Nephrology And Hypertension St. Marianna University School Of Medicine

• Kayaba Kazunori

  School Of Health And Social Services Saitama Prefectural Univ.

• Kataoka Keiichiro

  Department Of Pharmacology And Molecular Therapeutics Kumamoto University Graduate School Of Medical

• Kanatsu Kazuro

  Department Of Internal Medicine Hyogo Hospital

• Nakamura Yosikazu

  Division Of Epidemiology Miyagi Cancer Center Research Institute

• Goto Tadao

  Kokuho Wara Hospital

• Kaziwara Ko

  Department Of Cardiology Tenri Hospital

• Kitamura Kouichi

  Internal Medicine Nephrology And Hypertension St. Marianna University School Of Medicine

• Ishikawa Shizukiyo

  Division Of Community And Family Medicine Jichi Medical University School Of Medicine

• Kadota K

  Department Of Internal Medicine Hyogo Hospital

• Kanagawa Kenji

  Research Institute National Cardiovascular Center

• Kudoh Kei

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Kanao Koichiro

  Department Of Blood Purification Kidney Center Tokyo Women's Medical University

• Komamura Kazuo

  Department Of Cardiovascular Medicine National Cardiovascular Center

• Niwa Yoshimitsu

  自治医科大学 公衆衛生学

• Kodama Kazuhisa

  Cardiac Intensive Care Unit Of Osaka Police Hospital

• Kuwahara Koichiro

  Department Of Medicine And Clinical Sciences Graduate School Of Medicine Kyoto University

• Kamide Kei

  Division Of Cardiovascular Medicine Department Of Medicine School Of Medicine Jichi Medical Universi

• Kitamura Kouichi

  Department Of Cardiovascular Medicine Nephrology And Neurology Faculty Of Medicine And Dialysis Unit

• Kamide Kei

  Cardiovascular Division Osaka Police Hospital

• Kajii Eiji

  Division Of Community And Family Medicine Jichi Medical University

• Kubota Kaoru

  Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital

• Isikawa Sizukiyo

  Department Of Cardiology Jichi Medical School

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