Effect of Revision of Japanese Diagnostic Criterion for Fever in Kawasaki Disease on Treatment and Cardiovascular Outcome

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Background The aim of this study was to investigate the effect of a revision of the fever criterion for initial intravenous immunoglobulin (IVIG) treatment, and cardiovascular sequelae, in the new Japanese diagnostic criteria for Kawasaki disease. Methods and Results Patients who were reported in the 16^<th> and 18^<th> nationwide surveys in Japan were analyzed. New criteria group comprised patients who received the diagnosis of Kawasaki disease in the 18^<th> nationwide survey (n=18, 789). Old criteria group was comprised patients who received their diagnosis in the 16^<th> nationwide survey (n=15, 017). The difference between the new and old criteria for complete cases was only 1%. The proportion of patients who were treated with IVIG within 4 days of illness onset in the new criteria group was significantly lower than in the old criteria group (27.7% vs 30.7%). Multivariate logistic regression analysis identified criteria sex, age, recurrence, diagnosis, last day of initial IVIG and additional IVIG treatment as significant independent factors for cardiovascular sequelae. Conclusions The guideline revision improves diagnostic sensitivity somewhat, but reflects the clinical reality of the disease that approximately 30% of patients are treated with IVIG within 4 days of illness onset. (Circ J 2007; 71 : 1791-1793)
社団法人日本循環器学会の論文
2007-10-20